Exploring hydrogen peroxide responsive thiazolidinone-based prodrugs.
نویسندگان
چکیده
A novel approach for developing prodrugs based on masked carboxylic acids is described. Rather than using conventional esterase-based activation, thiazolidinone protecting groups have been identified that can reveal carboxylic acid groups upon activation by hydrogen peroxide. This may prove valuable in the continuing development of prodrug strategies that rely on reactive oxygen species (ROS) as a trigger.
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عنوان ژورنال:
- Chemical communications
دوره 51 33 شماره
صفحات -
تاریخ انتشار 2015